Author(s): Haitham Qutob
Background/Aims: This is a comparative study that aims to evaluate serum levels of ghrelin, resistin, insulin and identify possible correlations that may exist between these parameters in a population of an obese diabetic woman with metabolic syndrome and to assess their spontaneous alimentation. Methods: Measurement of ghrelin, resistin, glucose, insulin and lipid profile were performed in 53 obese diabetic women with metabolic syndrome and 52 healthy women subjects. A food survey was conducted in the study. Results: Our data show a significant difference in levels of ghrelin and resistin between the two groups. In fact, ghrelin level in obese diabetics is (25.46 ± 3.59 pg / ml) against (50.66 ± 6.84 pg / ml) for the control and resistin rate is (9.17 ± 1.68 ng / ml) against (3.17 ± 0.51 ng / ml) for the control group. A significant negative correlation was revealed between ghrelin and glucose (p = 0.003), ghrelin and insulin (p = 0.002) and ghrelin and resistin (p = 0.001). In addition, a significant positive correlation was found between resistin and BMI (p <0.001) likewise resistin and insulin (p<0.001). Our food survey showed a significant difference in nutrient intake between the two groups of the study (p<0.001). Conclusions: The present study revealed the relation of resistin and ghrelin to obesity associated with diabetes and metabolic syndrome, and the impact of diet on lipid parameters and metabolic profile
