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Mitochondrial dysfunction diseases represent a diverse group of disorders characterized by impaired cellular energy production, leading to a myriad of clinical manifestations across different organ systems. This abstract explores the underlying mechanisms of mitochondrial dysfunction, highlighting its impact on cellular energy metabolism and its association with various diseases. Through a comprehensive review of current literature, this paper elucidates the intricate interplay between mitochondrial function and overall cellular health. Understanding the molecular pathways involved in mitochondrial dysfunction is crucial for the development of targeted therapeutic interventions and personalized treatment strategies for affected individuals